Drug interactions
Elranatamab + Tizanidine
Severity: Moderate
Elranatamab and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elranatamab can cause cytokine release syndrome, which temporarily suppresses CYP enzyme activity, including CYP1A2, the main pathway for tizanidine metabolism. Tizanidine exposure may rise, with more hypotension, bradycardia and sedation, mainly around step-up dosing and during CRS.
What this interaction means in plain words
Elranatamab and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elranatamab belongs to Oncology; Tizanidine belongs to Musculoskeletal.
Why it happens
Cytokine-mediated suppression of CYP1A2 reduces tizanidine clearance.
What to do
Monitor blood pressure, heart rate and sedation during step-up dosing and any CRS episode. Reduce or hold tizanidine if hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Carbamazepine + Elranatamab Moderate
- Clomipramine + Elranatamab Moderate
- Clozapine + Elranatamab Moderate
Frequently asked questions
Can I take Elranatamab with Tizanidine?
MediHelp rates the interaction as moderate. Elranatamab and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elranatamab can cause cytokine release syndrome, which temporarily suppresses CYP enzyme activity, including CYP1A2, the main pathway for tizanidine metabolism. Tizanidine exposure may rise, with more hypotension, bradycardia and sedation, mainly around step-up dosing and during CRS.
How serious is the interaction between Elranatamab and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation during step-up dosing and any CRS episode. Reduce or hold tizanidine if hypotension or bradycardia occurs.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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