Drug interactions
Eltrombopag + Levoketoconazole
Severity: Moderate
Eltrombopag and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits several CYP enzymes and may raise eltrombopag exposure. Higher eltrombopag levels increase the risk of hepatotoxicity, and levoketoconazole itself carries a hepatotoxicity warning.
What this interaction means in plain words
Eltrombopag and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Levoketoconazole belongs to Endocrine.
Why it happens
Levoketoconazole inhibits CYP-mediated metabolism of eltrombopag, including CYP2C8 and CYP1A2.
What to do
Monitor liver function tests and platelet counts closely. Reduce the eltrombopag dose if platelet counts rise excessively or liver enzymes increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Eltrombopag with Levoketoconazole?
MediHelp rates the interaction as moderate. Eltrombopag and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole inhibits several CYP enzymes and may raise eltrombopag exposure. Higher eltrombopag levels increase the risk of hepatotoxicity, and levoketoconazole itself carries a hepatotoxicity warning.
How serious is the interaction between Eltrombopag and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and platelet counts closely. Reduce the eltrombopag dose if platelet counts rise excessively or liver enzymes increase.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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