Drug interactions
Eltrombopag + Ozanimod
Severity: Moderate
Eltrombopag and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits BCRP, which may raise exposure to the active metabolites of ozanimod. This could increase adverse effects such as bradycardia, hepatic enzyme elevation and infections.
What this interaction means in plain words
Eltrombopag and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Ozanimod belongs to Central Nervous System.
Why it happens
BCRP inhibition by eltrombopag may reduce efflux of ozanimod active metabolites and increase their exposure.
What to do
Monitor heart rate, liver enzymes and signs of infection when the drugs are combined. Consider an alternative if tolerability problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Eltrombopag with Ozanimod?
MediHelp rates the interaction as moderate. Eltrombopag and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eltrombopag inhibits BCRP, which may raise exposure to the active metabolites of ozanimod. This could increase adverse effects such as bradycardia, hepatic enzyme elevation and infections.
How serious is the interaction between Eltrombopag and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, liver enzymes and signs of infection when the drugs are combined. Consider an alternative if tolerability problems arise.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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