Drug interactions
Eltrombopag + Zileuton
Severity: Moderate
Eltrombopag and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag is metabolized in part by CYP1A2, so zileuton may raise its exposure. Higher levels could increase the risk of hepatotoxicity, but the effect has not been well characterized.
What this interaction means in plain words
Eltrombopag and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibits CYP1A2, which contributes to eltrombopag metabolism.
What to do
Monitor liver function tests and platelet counts during combined use. Adjust the eltrombopag dose according to platelet response and liver tests.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Zileuton?
MediHelp rates the interaction as moderate. Eltrombopag and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eltrombopag is metabolized in part by CYP1A2, so zileuton may raise its exposure. Higher levels could increase the risk of hepatotoxicity, but the effect has not been well characterized.
How serious is the interaction between Eltrombopag and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and platelet counts during combined use. Adjust the eltrombopag dose according to platelet response and liver tests.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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