Drug interactions
Eluxadoline + Fluconazole
Severity: Minor
Eluxadoline and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline metabolism is incompletely characterized, and inhibitors of CYP2C9 and CYP2C19 such as fluconazole could increase its exposure. This might increase adverse effects such as constipation, nausea and pancreatitis.
What this interaction means in plain words
Eluxadoline and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Fluconazole belongs to Anti Fungals.
Why it happens
Possible inhibition of CYP2C9 and CYP2C19 metabolism of eluxadoline by fluconazole; clinical effect not firmly established.
What to do
Monitor for constipation and abdominal pain, especially upper abdominal pain suggestive of pancreatitis. Stop eluxadoline if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Fluconazole?
MediHelp rates the interaction as minor. Eluxadoline and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline metabolism is incompletely characterized, and inhibitors of CYP2C9 and CYP2C19 such as fluconazole could increase its exposure. This might increase adverse effects such as constipation, nausea and pancreatitis.
How serious is the interaction between Eluxadoline and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation and abdominal pain, especially upper abdominal pain suggestive of pancreatitis. Stop eluxadoline if these occur.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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