Drug interactions
Eluxadoline + Fluvoxamine
Severity: Moderate
Eluxadoline and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline exposure may rise when given with strong CYP1A2 or CYP2C19 inhibitors such as fluvoxamine, although this has not been well studied. Higher exposure could increase adverse effects such as constipation, nausea and, rarely, pancreatitis.
What this interaction means in plain words
Eluxadoline and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Fluvoxamine belongs to Central Nervous System.
Why it happens
Fluvoxamine inhibits CYP1A2 and CYP2C19 and may reduce eluxadoline metabolism.
What to do
Monitor for constipation, abdominal pain and signs of pancreatitis, and stop eluxadoline if severe constipation or pancreatitis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Fluvoxamine?
MediHelp rates the interaction as moderate. Eluxadoline and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline exposure may rise when given with strong CYP1A2 or CYP2C19 inhibitors such as fluvoxamine, although this has not been well studied. Higher exposure could increase adverse effects such as constipation, nausea and, rarely, pancreatitis.
How serious is the interaction between Eluxadoline and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation, abdominal pain and signs of pancreatitis, and stop eluxadoline if severe constipation or pancreatitis develops.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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