Drug interactions
Eluxadoline + Hydroxyzine
Severity: Moderate
Eluxadoline and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine has anticholinergic activity that reduces gut motility, and eluxadoline can cause constipation and pancreatitis-related complications. Combining them may increase the risk of serious constipation-related adverse effects.
What this interaction means in plain words
Eluxadoline and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Hydroxyzine belongs to Respiratory.
Why it happens
Additive reduction of gastrointestinal motility from anticholinergic effect and opioid receptor agonism.
What to do
Monitor for constipation and stop eluxadoline if severe constipation develops. Consider an alternative to hydroxyzine if bowel symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Hydroxyzine?
MediHelp rates the interaction as moderate. Eluxadoline and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine has anticholinergic activity that reduces gut motility, and eluxadoline can cause constipation and pancreatitis-related complications. Combining them may increase the risk of serious constipation-related adverse effects.
How serious is the interaction between Eluxadoline and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation and stop eluxadoline if severe constipation develops. Consider an alternative to hydroxyzine if bowel symptoms worsen.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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