Drug interactions
Eluxadoline + Itraconazole
Severity: Moderate
Eluxadoline and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole could raise eluxadoline concentrations, although its metabolism is not fully characterized. Higher exposure might increase adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
What this interaction means in plain words
Eluxadoline and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Itraconazole belongs to Anti Fungals.
Why it happens
Possible CYP3A4 inhibition reducing eluxadoline clearance; the exact contribution is not well established.
What to do
Monitor for constipation, abdominal pain and pancreatitis symptoms. Stop eluxadoline if severe abdominal pain or constipation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Itraconazole?
MediHelp rates the interaction as moderate. Eluxadoline and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole could raise eluxadoline concentrations, although its metabolism is not fully characterized. Higher exposure might increase adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
How serious is the interaction between Eluxadoline and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation, abdominal pain and pancreatitis symptoms. Stop eluxadoline if severe abdominal pain or constipation develops.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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