Drug interactions
Eluxadoline + Lovastatin
Severity: Moderate
Eluxadoline and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lovastatin may inhibit OATP1B1 and raise eluxadoline exposure, increasing its adverse effects such as constipation, nausea and pancreatitis risk. The effect of OATP1B1 inhibitors on eluxadoline is documented in labeling.
What this interaction means in plain words
Eluxadoline and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Lovastatin belongs to Cardiovascular.
Why it happens
OATP1B1 inhibition reduces hepatic uptake of eluxadoline.
What to do
Reduce eluxadoline to 75 mg twice daily if combined with an OATP1B1 inhibitor and monitor for GI adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eluxadoline and Lovastatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Lovastatin?
MediHelp rates the interaction as moderate. Eluxadoline and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lovastatin may inhibit OATP1B1 and raise eluxadoline exposure, increasing its adverse effects such as constipation, nausea and pancreatitis risk. The effect of OATP1B1 inhibitors on eluxadoline is documented in labeling.
How serious is the interaction between Eluxadoline and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eluxadoline to 75 mg twice daily if combined with an OATP1B1 inhibitor and monitor for GI adverse effects.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
