Drug interactions
Eluxadoline + Midazolam
Severity: Moderate
Eluxadoline and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline may inhibit CYP3A4 and increase exposure to sensitive substrates such as midazolam. The effect is likely modest but may lengthen sedation.
What this interaction means in plain words
Eluxadoline and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Midazolam belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 metabolism of midazolam by eluxadoline.
What to do
Monitor sedation and consider a lower midazolam dose, particularly for oral use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Midazolam?
MediHelp rates the interaction as moderate. Eluxadoline and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline may inhibit CYP3A4 and increase exposure to sensitive substrates such as midazolam. The effect is likely modest but may lengthen sedation.
How serious is the interaction between Eluxadoline and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and consider a lower midazolam dose, particularly for oral use.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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