Drug interactions
Eluxadoline + Nitrofurantoin
Severity: Minor
Eluxadoline and Nitrofurantoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline inhibits BCRP and may increase exposure to BCRP substrates such as nitrofurantoin. The effect is probably small and clinical relevance is unclear.
What this interaction means in plain words
Eluxadoline and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Nitrofurantoin belongs to Anti Bacterial.
Why it happens
Inhibition of BCRP transport by eluxadoline, not a change in metabolism.
What to do
No dose change is usually needed. Monitor for nausea, neuropathy or pulmonary symptoms if nitrofurantoin is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Nitrofurantoin?
MediHelp rates the interaction as minor. Eluxadoline and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline inhibits BCRP and may increase exposure to BCRP substrates such as nitrofurantoin. The effect is probably small and clinical relevance is unclear.
How serious is the interaction between Eluxadoline and Nitrofurantoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for nausea, neuropathy or pulmonary symptoms if nitrofurantoin is prolonged.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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