Drug interactions
Eluxadoline + Omeprazole
Severity: Minor
Eluxadoline and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline metabolism is incompletely characterised, and CYP2C19 inhibition might raise its exposure. Increased exposure could worsen constipation, pancreatitis risk or CNS effects, but data are limited and omeprazole is a modest inhibitor.
What this interaction means in plain words
Eluxadoline and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Possible reduced eluxadoline clearance via CYP2C19 inhibition by omeprazole; not firmly established.
What to do
No routine adjustment is needed. Monitor for constipation, abdominal pain and signs of pancreatitis.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Omeprazole?
MediHelp rates the interaction as minor. Eluxadoline and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline metabolism is incompletely characterised, and CYP2C19 inhibition might raise its exposure. Increased exposure could worsen constipation, pancreatitis risk or CNS effects, but data are limited and omeprazole is a modest inhibitor.
How serious is the interaction between Eluxadoline and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for constipation, abdominal pain and signs of pancreatitis.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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