Drug interactions
Eluxadoline + Pentazocine
Severity: Moderate
Eluxadoline and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is a mu-opioid receptor agonist used for IBS with diarrhea, and it can cause constipation and pancreatitis-related events. Opioids such as pentazocine add to constipating effects and may raise the risk of serious constipation-related complications.
What this interaction means in plain words
Eluxadoline and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Pentazocine belongs to Musculoskeletal.
Why it happens
Additive opioid-receptor-mediated reduction of gastrointestinal motility.
What to do
Avoid combining with other constipating opioids where possible. Monitor bowel function and stop eluxadoline if severe constipation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Pentazocine?
MediHelp rates the interaction as moderate. Eluxadoline and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline is a mu-opioid receptor agonist used for IBS with diarrhea, and it can cause constipation and pancreatitis-related events. Opioids such as pentazocine add to constipating effects and may raise the risk of serious constipation-related complications.
How serious is the interaction between Eluxadoline and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with other constipating opioids where possible. Monitor bowel function and stop eluxadoline if severe constipation develops.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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