Drug interactions
Eluxadoline + Pravastatin
Severity: Minor
Eluxadoline and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pravastatin is an OATP1B1 substrate and is not a known significant inhibitor, so it is unlikely to raise eluxadoline exposure in a relevant way. The labeled dose reduction applies to strong OATP1B1 inhibitors such as cyclosporine, not to pravastatin.
What this interaction means in plain words
Eluxadoline and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Pravastatin belongs to Cardiovascular.
Why it happens
Possible competition at OATP1B1 transport; not clinically established.
What to do
No dose adjustment is generally needed; monitor for eluxadoline adverse effects such as constipation or pancreatitis symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Pravastatin?
MediHelp rates the interaction as minor. Eluxadoline and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pravastatin is an OATP1B1 substrate and is not a known significant inhibitor, so it is unlikely to raise eluxadoline exposure in a relevant way. The labeled dose reduction applies to strong OATP1B1 inhibitors such as cyclosporine, not to pravastatin.
How serious is the interaction between Eluxadoline and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for eluxadoline adverse effects such as constipation or pancreatitis symptoms.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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