Drug interactions
Eluxadoline + Rosuvastatin
Severity: Moderate
Eluxadoline and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline raises systemic exposure to rosuvastatin, increasing the potential for myopathy and rhabdomyolysis. The effect is relevant particularly at higher statin doses.
What this interaction means in plain words
Eluxadoline and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Rosuvastatin belongs to Cardiovascular.
Why it happens
Eluxadoline inhibits OATP1B1 and BCRP, reducing hepatic uptake and efflux of rosuvastatin and raising plasma levels.
What to do
Use the lowest effective rosuvastatin dose and monitor for muscle symptoms. Check creatine kinase if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Rosuvastatin?
MediHelp rates the interaction as moderate. Eluxadoline and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline raises systemic exposure to rosuvastatin, increasing the potential for myopathy and rhabdomyolysis. The effect is relevant particularly at higher statin doses.
How serious is the interaction between Eluxadoline and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective rosuvastatin dose and monitor for muscle symptoms. Check creatine kinase if symptoms develop.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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