Drug interactions
Eluxadoline + Sirolimus
Severity: Minor
Eluxadoline and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline may modestly raise exposure to CYP3A substrates, and sirolimus has a narrow therapeutic index. Increased sirolimus concentrations could worsen adverse effects such as hyperlipidemia, cytopenias, edema and impaired wound healing.
What this interaction means in plain words
Eluxadoline and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Sirolimus belongs to Miscellaneous.
Why it happens
Possible weak inhibition of CYP3A4 by eluxadoline reduces sirolimus metabolism.
What to do
Check sirolimus trough concentrations after eluxadoline is started or stopped and adjust the sirolimus dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Sirolimus?
MediHelp rates the interaction as minor. Eluxadoline and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline may modestly raise exposure to CYP3A substrates, and sirolimus has a narrow therapeutic index. Increased sirolimus concentrations could worsen adverse effects such as hyperlipidemia, cytopenias, edema and impaired wound healing.
How serious is the interaction between Eluxadoline and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sirolimus trough concentrations after eluxadoline is started or stopped and adjust the sirolimus dose if needed.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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