Drug interactions
Eluxadoline + Tacrolimus
Severity: Moderate
Eluxadoline and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may inhibit OATP1B1 and so raise eluxadoline exposure, increasing its adverse effects such as constipation, pancreatitis and nausea. The effect is predicted from the transporter mechanism rather than shown clinically.
What this interaction means in plain words
Eluxadoline and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Tacrolimus belongs to Miscellaneous.
Why it happens
Inhibition of hepatic OATP1B1 uptake of eluxadoline, raising its systemic concentrations.
What to do
Consider reducing eluxadoline to 75 mg twice daily during coadministration. Monitor for constipation, abdominal pain and signs of pancreatitis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eluxadoline and Tacrolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Tacrolimus?
MediHelp rates the interaction as moderate. Eluxadoline and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus may inhibit OATP1B1 and so raise eluxadoline exposure, increasing its adverse effects such as constipation, pancreatitis and nausea. The effect is predicted from the transporter mechanism rather than shown clinically.
How serious is the interaction between Eluxadoline and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing eluxadoline to 75 mg twice daily during coadministration. Monitor for constipation, abdominal pain and signs of pancreatitis.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
