Drug interactions
Eluxadoline + Tapentadol
Severity: Moderate
Eluxadoline and Tapentadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is used for diarrhea-predominant IBS and can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Tapentadol is an opioid that slows gut motility, so combined use raises the risk of severe constipation.
What this interaction means in plain words
Eluxadoline and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Tapentadol belongs to Musculoskeletal.
Why it happens
Additive reduction of gastrointestinal motility via opioid receptor activity.
What to do
Avoid the combination if possible; if used, monitor bowel function and stop eluxadoline if severe constipation develops. Report severe abdominal pain promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Tapentadol?
MediHelp rates the interaction as moderate. Eluxadoline and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline is used for diarrhea-predominant IBS and can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Tapentadol is an opioid that slows gut motility, so combined use raises the risk of severe constipation.
How serious is the interaction between Eluxadoline and Tapentadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if used, monitor bowel function and stop eluxadoline if severe constipation develops. Report severe abdominal pain promptly.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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