Drug interactions
Eluxadoline + Tipranavir
Severity: Moderate
Eluxadoline and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir inhibits hepatic OATP1B1 uptake and raises eluxadoline exposure. Higher levels increase the risk of adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
What this interaction means in plain words
Eluxadoline and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of eluxadoline increases systemic concentrations.
What to do
Reduce eluxadoline to 75 mg twice daily during co-administration. Monitor for constipation, abdominal pain and signs of pancreatitis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eluxadoline
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Eluxadoline with Tipranavir?
MediHelp rates the interaction as moderate. Eluxadoline and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir inhibits hepatic OATP1B1 uptake and raises eluxadoline exposure. Higher levels increase the risk of adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
How serious is the interaction between Eluxadoline and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eluxadoline to 75 mg twice daily during co-administration. Monitor for constipation, abdominal pain and signs of pancreatitis.
What other medicines interact with Eluxadoline?
MediHelp also lists interactions of Eluxadoline with, for example, Alosetron, Atropine, Buprenorphine. The full list is on the Eluxadoline page.
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