Drug interactions
Eluxadoline + Voriconazole
Severity: Minor
Eluxadoline and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise eluxadoline exposure, which could increase adverse effects such as constipation, nausea and pancreatitis. Eluxadoline's metabolism is incompletely characterized.
What this interaction means in plain words
Eluxadoline and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Voriconazole belongs to Anti Fungals.
Why it happens
Possible inhibition of CYP-mediated metabolism; eluxadoline is mainly eliminated unchanged in feces, so the mechanism is not firmly established.
What to do
Monitor for gastrointestinal adverse effects and pancreatitis symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Voriconazole?
MediHelp rates the interaction as minor. Eluxadoline and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole may raise eluxadoline exposure, which could increase adverse effects such as constipation, nausea and pancreatitis. Eluxadoline's metabolism is incompletely characterized.
How serious is the interaction between Eluxadoline and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal adverse effects and pancreatitis symptoms.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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