Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fenofibrate
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fenofibrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate is not significantly cleared by CYP3A4, so cobicistat is unlikely to raise its exposure meaningfully. No clinically important interaction is expected, and the legacy contraindication does not apply.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Fenofibrate is mainly hydrolyzed to fenofibric acid and glucuronidated, so CYP3A4 inhibition has little effect.
What to do
No dose adjustment is needed; monitor lipids and renal function as usual, given tenofovir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Fenofibrate?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibrate is not significantly cleared by CYP3A4, so cobicistat is unlikely to raise its exposure meaningfully. No clinically important interaction is expected, and the legacy contraindication does not apply.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fenofibrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor lipids and renal function as usual, given tenofovir.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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