Drug interactions
Empagliflozin-metformin + Liothyronine
Severity: Moderate
Empagliflozin-metformin and Liothyronine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone increases metabolic rate and hepatic glucose output, which can raise blood glucose in diabetic patients. Glycemic control may worsen, and requirements can change when thyroid doses are adjusted.
What this interaction means in plain words
Empagliflozin-metformin and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Liothyronine belongs to Endocrine.
Why it happens
Thyroid hormone increases hepatic gluconeogenesis and glucose absorption, opposing antidiabetic effects.
What to do
Monitor blood glucose and HbA1c when starting or changing liothyronine. Adjust antidiabetic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Empagliflozin-metformin with Liothyronine?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone increases metabolic rate and hepatic glucose output, which can raise blood glucose in diabetic patients. Glycemic control may worsen, and requirements can change when thyroid doses are adjusted.
How serious is the interaction between Empagliflozin-metformin and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting or changing liothyronine. Adjust antidiabetic doses accordingly.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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