Drug interactions
Empagliflozin-metformin + Medroxyprogesterone
Severity: Minor
Empagliflozin-metformin and Medroxyprogesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins can cause reduced glucose tolerance and may raise blood glucose in some patients. This may modestly weaken the control achieved with empagliflozin-metformin.
What this interaction means in plain words
Empagliflozin-metformin and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-metformin belongs to Endocrine; Medroxyprogesterone belongs to Endocrine.
Why it happens
Progestogens can induce insulin resistance, opposing antidiabetic effect pharmacodynamically.
What to do
Monitor glucose when starting or stopping medroxyprogesterone, especially with depot dosing, and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-metformin
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Empagliflozin-metformin with Medroxyprogesterone?
MediHelp rates the interaction as minor. Empagliflozin-metformin and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins can cause reduced glucose tolerance and may raise blood glucose in some patients. This may modestly weaken the control achieved with empagliflozin-metformin.
How serious is the interaction between Empagliflozin-metformin and Medroxyprogesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting or stopping medroxyprogesterone, especially with depot dosing, and adjust antidiabetic therapy if needed.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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