Drug interactions
Empagliflozin-metformin + Pentamidine
Severity: Moderate
Empagliflozin-metformin and Pentamidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine can damage pancreatic beta cells, causing insulin release with hypoglycemia, followed by insulin deficiency and hyperglycemia or diabetes. This unpredictable glucose disturbance can destabilize control in patients on antidiabetic therapy.
What this interaction means in plain words
Empagliflozin-metformin and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Pentamidine belongs to Anti Parasitic.
Why it happens
Pentamidine is toxic to pancreatic beta cells, causing dysglycemia that is independent of but confounds antidiabetic therapy.
What to do
Monitor blood glucose closely during and after pentamidine therapy and counsel on symptoms of hypo- and hyperglycemia. Adjust antidiabetic therapy according to readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Empagliflozin-metformin with Pentamidine?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentamidine can damage pancreatic beta cells, causing insulin release with hypoglycemia, followed by insulin deficiency and hyperglycemia or diabetes. This unpredictable glucose disturbance can destabilize control in patients on antidiabetic therapy.
How serious is the interaction between Empagliflozin-metformin and Pentamidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and after pentamidine therapy and counsel on symptoms of hypo- and hyperglycemia. Adjust antidiabetic therapy according to readings.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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