Drug interactions
Empagliflozin-metformin + Prochlorperazine
Severity: Moderate
Empagliflozin-metformin and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines like prochlorperazine can cause hyperglycemia and impair glucose tolerance, which may blunt the effect of metformin and empagliflozin. The effect is usually modest at antiemetic doses but can matter with prolonged use.
What this interaction means in plain words
Empagliflozin-metformin and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Prochlorperazine belongs to Central Nervous System.
Why it happens
Phenothiazine-related reduced insulin secretion and increased insulin resistance oppose the antidiabetic effect.
What to do
Monitor blood glucose when prochlorperazine is used regularly or long term and adjust antidiabetic therapy if needed. Recheck glucose after the phenothiazine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Empagliflozin-metformin with Prochlorperazine?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines like prochlorperazine can cause hyperglycemia and impair glucose tolerance, which may blunt the effect of metformin and empagliflozin. The effect is usually modest at antiemetic doses but can matter with prolonged use.
How serious is the interaction between Empagliflozin-metformin and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when prochlorperazine is used regularly or long term and adjust antidiabetic therapy if needed. Recheck glucose after the phenothiazine is stopped.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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