Drug interactions
Enalapril + Icatibant
Severity: Minor
Enalapril and Icatibant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icatibant blocks bradykinin B2 receptors, and part of the blood pressure lowering of ACE inhibitors depends on raised bradykinin. Icatibant may therefore weaken enalapril's antihypertensive effect. This is mainly theoretical, and icatibant is used short term for ACE-inhibitor or hereditary angioedema attacks.
What this interaction means in plain words
Enalapril and Icatibant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril belongs to Cardiovascular; Icatibant belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism through bradykinin B2 receptor blockade, opposing the bradykinin-mediated component of ACE inhibitor effects.
What to do
Monitor blood pressure after icatibant use; no dose adjustment is usually needed. If treating ACE-inhibitor angioedema, stop enalapril.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Icatibant
Frequently asked questions
Can I take Enalapril with Icatibant?
MediHelp rates the interaction as minor. Enalapril and Icatibant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icatibant blocks bradykinin B2 receptors, and part of the blood pressure lowering of ACE inhibitors depends on raised bradykinin. Icatibant may therefore weaken enalapril's antihypertensive effect. This is mainly theoretical, and icatibant is used short term for ACE-inhibitor or hereditary angioedema attacks.
How serious is the interaction between Enalapril and Icatibant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after icatibant use; no dose adjustment is usually needed. If treating ACE-inhibitor angioedema, stop enalapril.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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