Drug interactions
Enalapril-hydrochlorothiazide + Entecavir
Severity: Minor
Enalapril-hydrochlorothiazide and Entecavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir is eliminated mainly by the kidney through filtration and active tubular secretion. Drugs that impair renal function or compete for tubular secretion could raise concentrations of entecavir or the co-administered drug. The clinical effect with enalapril and hydrochlorothiazide is expected to be small.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Entecavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Entecavir belongs to Anti Virals.
Why it happens
Possible competition for renal tubular secretion and reduced renal function, which may lower renal clearance of entecavir.
What to do
No routine change is needed; monitor renal function in patients with renal impairment and adjust the entecavir dose to creatinine clearance per labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Entecavir
- Alogliptin-metformin + Entecavir Moderate
- Canagliflozin-metformin + Entecavir Moderate
- Cidofovir + Entecavir Moderate
- Cyclosporine + Entecavir Moderate
- Dapagliflozin-metformin + Entecavir Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Entecavir Moderate
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Entecavir?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Entecavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entecavir is eliminated mainly by the kidney through filtration and active tubular secretion. Drugs that impair renal function or compete for tubular secretion could raise concentrations of entecavir or the co-administered drug. The clinical effect with enalapril and hydrochlorothiazide is expected to be small.
How serious is the interaction between Enalapril-hydrochlorothiazide and Entecavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor renal function in patients with renal impairment and adjust the entecavir dose to creatinine clearance per labeling.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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