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Drug interactions

Enalapril-hydrochlorothiazide + Everolimus

Severity: Major

Enalapril-hydrochlorothiazide and Everolimus: major interaction.

Last updated Sources: US FDA label

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Everolimus combined with an ACE inhibitor increases the risk of angioedema, which may involve the airway and be life-threatening. It can occur at any time during treatment.

What this interaction means in plain words

Enalapril-hydrochlorothiazide and Everolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Enalapril-hydrochlorothiazide belongs to Cardiovascular; Everolimus belongs to Oncology.

Evidence level: Moderate

Why it happens

mTOR inhibition may impair bradykinin breakdown, adding to ACE inhibitor-induced bradykinin accumulation.

What to do

Counsel patients to report swelling of the face, lips, tongue or throat immediately. Consider a non-ACE inhibitor antihypertensive alternative, and stop enalapril if angioedema occurs.

What to ask your pharmacist

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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References

Frequently asked questions

Can I take Enalapril-hydrochlorothiazide with Everolimus?

MediHelp rates the interaction as major. Enalapril-hydrochlorothiazide and Everolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Everolimus combined with an ACE inhibitor increases the risk of angioedema, which may involve the airway and be life-threatening. It can occur at any time during treatment.

How serious is the interaction between Enalapril-hydrochlorothiazide and Everolimus?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report swelling of the face, lips, tongue or throat immediately. Consider a non-ACE inhibitor antihypertensive alternative, and stop enalapril if angioedema occurs.

What other medicines interact with Enalapril-hydrochlorothiazide?

MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.

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