Drug interactions
Enalapril-hydrochlorothiazide + Finerenone
Severity: Major
Enalapril-hydrochlorothiazide and Finerenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Finerenone is a mineralocorticoid receptor antagonist and raises serum potassium, as do ACE inhibitors. Combined use increases the risk of hyperkalemia, although the thiazide partly offsets it.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Finerenone belongs to Cardiovascular.
Why it happens
Additive reduction in renal potassium excretion from mineralocorticoid receptor blockade and ACE inhibition.
What to do
Check serum potassium before starting and during the first weeks, then periodically, and adjust or interrupt finerenone per labeling according to potassium level.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Finerenone?
MediHelp rates the interaction as major. Enalapril-hydrochlorothiazide and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Finerenone is a mineralocorticoid receptor antagonist and raises serum potassium, as do ACE inhibitors. Combined use increases the risk of hyperkalemia, although the thiazide partly offsets it.
How serious is the interaction between Enalapril-hydrochlorothiazide and Finerenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium before starting and during the first weeks, then periodically, and adjust or interrupt finerenone per labeling according to potassium level.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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