Drug interactions
Enalapril-hydrochlorothiazide + Glipizide
Severity: Moderate
Enalapril-hydrochlorothiazide and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. Thiazides, by contrast, tend to raise glucose and may offset this effect, so the net result is variable.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Glipizide belongs to Endocrine.
Why it happens
ACE inhibition may improve insulin sensitivity (additive pharmacodynamic effect), while thiazides may impair glucose tolerance.
What to do
Monitor blood glucose, especially in the first weeks after starting or changing the combination. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Glipizide
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Glipizide?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and may enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. Thiazides, by contrast, tend to raise glucose and may offset this effect, so the net result is variable.
How serious is the interaction between Enalapril-hydrochlorothiazide and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, especially in the first weeks after starting or changing the combination. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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