Drug interactions
Enalapril-hydrochlorothiazide + Methylprednisolone
Severity: Minor
Enalapril-hydrochlorothiazide and Methylprednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids can increase potassium excretion, adding to the potassium loss from hydrochlorothiazide. Hypokalemia is more likely with higher doses and prolonged courses. Methylprednisolone has little mineralocorticoid activity, so the effect is usually modest.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Methylprednisolone belongs to Endocrine.
Why it happens
Additive renal potassium loss from corticosteroid and thiazide effects.
What to do
Monitor serum potassium during prolonged or high-dose corticosteroid therapy and replace as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Methylprednisolone?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic corticosteroids can increase potassium excretion, adding to the potassium loss from hydrochlorothiazide. Hypokalemia is more likely with higher doses and prolonged courses. Methylprednisolone has little mineralocorticoid activity, so the effect is usually modest.
How serious is the interaction between Enalapril-hydrochlorothiazide and Methylprednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during prolonged or high-dose corticosteroid therapy and replace as needed.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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