Drug interactions
Enalapril-hydrochlorothiazide + Pretomanid
Severity: Minor
Enalapril-hydrochlorothiazide and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid may inhibit OATP1B3, which could modestly raise exposure to substrates such as enalapril. The clinical relevance is not well characterised and is likely small.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
Why it happens
Possible inhibition of OATP1B3-mediated hepatic uptake by pretomanid, predicted from in vitro data.
What to do
No dose change is usually needed. Monitor blood pressure and renal function if enalapril effects appear exaggerated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Enalapril-hydrochlorothiazide and Pretomanid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Pretomanid?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid may inhibit OATP1B3, which could modestly raise exposure to substrates such as enalapril. The clinical relevance is not well characterised and is likely small.
How serious is the interaction between Enalapril-hydrochlorothiazide and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor blood pressure and renal function if enalapril effects appear exaggerated.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
