Drug interactions
Enalapril-hydrochlorothiazide + Vitamin d
Severity: Moderate
Enalapril-hydrochlorothiazide and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce urinary calcium excretion, and with vitamin D or its analogs this can cause hypercalcemia. The risk is greater with high doses, calcium supplements or renal impairment.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Thiazide enhances renal calcium reabsorption while vitamin D increases intestinal calcium absorption.
What to do
Monitor serum calcium and renal function periodically, especially when doses are high. Reduce vitamin D or calcium supplements if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Vitamin d
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Vitamin d?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, and with vitamin D or its analogs this can cause hypercalcemia. The risk is greater with high doses, calcium supplements or renal impairment.
How serious is the interaction between Enalapril-hydrochlorothiazide and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function periodically, especially when doses are high. Reduce vitamin D or calcium supplements if hypercalcemia develops.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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