Drug interactions
Encorafenib + Ezetimibe
Severity: Minor
Encorafenib and Ezetimibe: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib inhibits OATP1B1 and may raise ezetimibe concentrations. The clinical consequence is likely modest given ezetimibe's wide tolerability.
What this interaction means in plain words
Encorafenib and Ezetimibe have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Encorafenib belongs to Oncology; Ezetimibe belongs to Cardiovascular.
Why it happens
OATP1B1 inhibition by encorafenib reduces hepatic uptake of ezetimibe and its glucuronide.
What to do
No dose change is usually needed; monitor for adverse effects such as liver enzyme elevation or myalgia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ezetimibe
- Apalutamide + Ezetimibe Moderate
- Cholestyramine + Ezetimibe Moderate
- Cyclosporin + Ezetimibe Moderate
- Ezetimibe + Gemfibrozil Moderate
- Ezetimibe + Glecaprevir / pibrentasvir Moderate
- Ezetimibe + Letermovir Moderate
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Ezetimibe?
MediHelp rates the interaction as minor. Encorafenib and Ezetimibe have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Encorafenib inhibits OATP1B1 and may raise ezetimibe concentrations. The clinical consequence is likely modest given ezetimibe's wide tolerability.
How serious is the interaction between Encorafenib and Ezetimibe?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for adverse effects such as liver enzyme elevation or myalgia.
What other medicines interact with Ezetimibe?
MediHelp also lists interactions of Ezetimibe with, for example, Apalutamide, Cholestyramine, Cyclosporin. The full list is on the Ezetimibe page.
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