Drug interactions
Encorafenib + Tenofovir alafenamide
Severity: Minor
Encorafenib and Tenofovir alafenamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib may inhibit BCRP and could slightly increase absorption of tenofovir alafenamide. The clinical impact is expected to be small given the wide safety margin of tenofovir alafenamide.
What this interaction means in plain words
Encorafenib and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Encorafenib belongs to Oncology; Tenofovir alafenamide belongs to Anti Virals.
Why it happens
Predicted inhibition of intestinal BCRP efflux by encorafenib.
What to do
No dose change is generally needed. Follow routine renal and bone monitoring for tenofovir alafenamide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Tenofovir alafenamide?
MediHelp rates the interaction as minor. Encorafenib and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Encorafenib may inhibit BCRP and could slightly increase absorption of tenofovir alafenamide. The clinical impact is expected to be small given the wide safety margin of tenofovir alafenamide.
How serious is the interaction between Encorafenib and Tenofovir alafenamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Follow routine renal and bone monitoring for tenofovir alafenamide.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
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