Drug interactions
Berotralstat + Tenofovir alafenamide
Severity: Moderate
Berotralstat and Tenofovir alafenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein, and tenofovir alafenamide is a P-gp substrate whose absorption depends on this transporter. Coadministration may increase tenofovir alafenamide exposure, though the clinical impact is likely modest given its low systemic dose.
What this interaction means in plain words
Berotralstat and Tenofovir alafenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Tenofovir alafenamide belongs to Anti Virals.
Why it happens
Inhibition of intestinal P-glycoprotein by berotralstat increases absorption of tenofovir alafenamide.
What to do
Monitor for tenofovir adverse effects, including renal function, during coadministration. Dose changes are generally not required unless toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
- Tenofovir alafenamide + Tepotinib Moderate
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Tenofovir alafenamide?
MediHelp rates the interaction as moderate. Berotralstat and Tenofovir alafenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein, and tenofovir alafenamide is a P-gp substrate whose absorption depends on this transporter. Coadministration may increase tenofovir alafenamide exposure, though the clinical impact is likely modest given its low systemic dose.
How serious is the interaction between Berotralstat and Tenofovir alafenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tenofovir adverse effects, including renal function, during coadministration. Dose changes are generally not required unless toxicity emerges.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Danicopan, Ifosfamide. The full list is on the Tenofovir alafenamide page.
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