Drug interactions
Danicopan + Tenofovir alafenamide
Severity: Moderate
Danicopan and Tenofovir alafenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and BCRP, which limit intestinal absorption of tenofovir alafenamide. Coadministration may raise tenofovir alafenamide exposure and thus tenofovir levels, although the increase is expected to be modest.
What this interaction means in plain words
Danicopan and Tenofovir alafenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Tenofovir alafenamide belongs to Anti Virals.
Why it happens
Danicopan inhibits intestinal P-gp and BCRP efflux, increasing absorption of tenofovir alafenamide.
What to do
Monitor for tenofovir-related adverse effects, particularly renal function and bone parameters, during coadministration. No empiric dose change is generally needed, but review if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
- Tenofovir alafenamide + Tepotinib Moderate
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Tenofovir alafenamide?
MediHelp rates the interaction as moderate. Danicopan and Tenofovir alafenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and BCRP, which limit intestinal absorption of tenofovir alafenamide. Coadministration may raise tenofovir alafenamide exposure and thus tenofovir levels, although the increase is expected to be modest.
How serious is the interaction between Danicopan and Tenofovir alafenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tenofovir-related adverse effects, particularly renal function and bone parameters, during coadministration. No empiric dose change is generally needed, but review if toxicity develops.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Ifosfamide. The full list is on the Tenofovir alafenamide page.
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