Drug interactions
Sotorasib + Tenofovir alafenamide
Severity: Moderate
Sotorasib and Tenofovir alafenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a weak P-gp inhibitor and a CYP3A4 inducer. The in vivo effect on tenofovir alafenamide has not been well characterised, and exposure could change modestly.
What this interaction means in plain words
Sotorasib and Tenofovir alafenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sotorasib belongs to Oncology; Tenofovir alafenamide belongs to Anti Virals.
Why it happens
Sotorasib modulates intestinal P-gp and induces CYP3A4, which could alter tenofovir alafenamide absorption and metabolism; the net effect is not established.
What to do
Monitor HIV or hepatitis B virologic response and renal function if the combination is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sotorasib and Tenofovir alafenamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Tenofovir alafenamide + Tepotinib Moderate
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Sotorasib with Tenofovir alafenamide?
MediHelp rates the interaction as moderate. Sotorasib and Tenofovir alafenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a weak P-gp inhibitor and a CYP3A4 inducer. The in vivo effect on tenofovir alafenamide has not been well characterised, and exposure could change modestly.
How serious is the interaction between Sotorasib and Tenofovir alafenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV or hepatitis B virologic response and renal function if the combination is needed.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
