Drug interactions
Ifosfamide + Tenofovir alafenamide
Severity: Moderate
Ifosfamide and Tenofovir alafenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide is well known to cause proximal tubular injury, Fanconi-type syndrome and reduced glomerular filtration. Tenofovir products can also affect the kidney, so combined use may add to renal toxicity, although tenofovir alafenamide is less nephrotoxic than the disoproxil form.
What this interaction means in plain words
Ifosfamide and Tenofovir alafenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Tenofovir alafenamide belongs to Anti Virals.
Why it happens
Additive nephrotoxic effects on the renal proximal tubule.
What to do
Monitor serum creatinine, phosphate, potassium and urinalysis before and during therapy, and reassess the antiviral regimen if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
- Tenofovir alafenamide + Tepotinib Moderate
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Tenofovir alafenamide?
MediHelp rates the interaction as moderate. Ifosfamide and Tenofovir alafenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide is well known to cause proximal tubular injury, Fanconi-type syndrome and reduced glomerular filtration. Tenofovir products can also affect the kidney, so combined use may add to renal toxicity, although tenofovir alafenamide is less nephrotoxic than the disoproxil form.
How serious is the interaction between Ifosfamide and Tenofovir alafenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate, potassium and urinalysis before and during therapy, and reassess the antiviral regimen if renal function worsens.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
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