Drug interactions
Orlistat + Tenofovir alafenamide
Severity: Moderate
Orlistat and Tenofovir alafenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loss of virological control has been reported in patients on antiretrovirals who took orlistat. Reduced absorption of the antiretroviral could lead to subtherapeutic levels and resistance.
What this interaction means in plain words
Orlistat and Tenofovir alafenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orlistat belongs to Miscellaneous; Tenofovir alafenamide belongs to Anti Virals.
Why it happens
Orlistat may reduce absorption of the antiretroviral, but the mechanism is not clearly established.
What to do
Monitor HIV RNA closely if orlistat is used. Stop orlistat if viral load rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
- Tenofovir alafenamide + Tepotinib Moderate
Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
Frequently asked questions
Can I take Orlistat with Tenofovir alafenamide?
MediHelp rates the interaction as moderate. Orlistat and Tenofovir alafenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loss of virological control has been reported in patients on antiretrovirals who took orlistat. Reduced absorption of the antiretroviral could lead to subtherapeutic levels and resistance.
How serious is the interaction between Orlistat and Tenofovir alafenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV RNA closely if orlistat is used. Stop orlistat if viral load rises.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
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