Drug interactions
Enoxaparin + Nintedanib
Severity: Moderate
Enoxaparin and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nintedanib inhibits VEGF receptors and has been associated with increased bleeding. Full-dose enoxaparin may add to that risk.
What this interaction means in plain words
Enoxaparin and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enoxaparin belongs to Cardiovascular; Nintedanib belongs to Oncology.
Why it happens
VEGFR inhibition can impair vascular integrity and hemostasis, adding to the anticoagulant effect of enoxaparin.
What to do
Use full-dose anticoagulation only if the benefit outweighs the risk, and monitor for bleeding. Check hemoglobin and platelets as clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Enoxaparin with Nintedanib?
MediHelp rates the interaction as moderate. Enoxaparin and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nintedanib inhibits VEGF receptors and has been associated with increased bleeding. Full-dose enoxaparin may add to that risk.
How serious is the interaction between Enoxaparin and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use full-dose anticoagulation only if the benefit outweighs the risk, and monitor for bleeding. Check hemoglobin and platelets as clinically indicated.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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