Drug interactions
Entacapone + Lonafarnib
Severity: Minor
Entacapone and Lonafarnib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A4 substrate whose exposure rises markedly with CYP3A inhibitors, and its labeling contraindicates strong and moderate inhibitors. Entacapone is not an established CYP3A4 inhibitor, so the basis of this listing is doubtful.
What this interaction means in plain words
Entacapone and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entacapone belongs to Central Nervous System; Lonafarnib belongs to Miscellaneous.
Why it happens
No established CYP3A4 inhibition by entacapone; any interaction is theoretical.
What to do
No specific action is needed beyond monitoring for lonafarnib adverse effects such as gastrointestinal toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Entacapone with Lonafarnib?
MediHelp rates the interaction as minor. Entacapone and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a sensitive CYP3A4 substrate whose exposure rises markedly with CYP3A inhibitors, and its labeling contraindicates strong and moderate inhibitors. Entacapone is not an established CYP3A4 inhibitor, so the basis of this listing is doubtful.
How serious is the interaction between Entacapone and Lonafarnib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond monitoring for lonafarnib adverse effects such as gastrointestinal toxicity.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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