Drug interactions
Entecavir + Linagliptin-metformin
Severity: Moderate
Entecavir and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir labeling warns of lactic acidosis, and metformin carries the same risk. Using both may theoretically increase the risk, especially in renal impairment or hepatic disease.
What this interaction means in plain words
Entecavir and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entecavir belongs to Anti Virals; Linagliptin-metformin belongs to Endocrine.
Why it happens
Additive risk of lactic acidosis from nucleoside analogue mitochondrial effects and metformin-related impaired lactate clearance.
What to do
Monitor for symptoms of lactic acidosis and check renal and hepatic function periodically; stop therapy if lactic acidosis is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Entecavir and Linagliptin-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Linagliptin-metformin
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Entecavir and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entecavir labeling warns of lactic acidosis, and metformin carries the same risk. Using both may theoretically increase the risk, especially in renal impairment or hepatic disease.
How serious is the interaction between Entecavir and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for symptoms of lactic acidosis and check renal and hepatic function periodically; stop therapy if lactic acidosis is suspected.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
