Drug interactions
Entecavir + Neomycin
Severity: Minor
Entecavir and Neomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir is eliminated mainly by the kidney, and drugs that impair renal function can raise its concentrations. Oral neomycin has minimal systemic absorption, so a meaningful effect is unlikely unless significant absorption and nephrotoxicity occur.
What this interaction means in plain words
Entecavir and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entecavir belongs to Anti Virals; Neomycin belongs to Anti Bacterial.
Why it happens
Theoretical competition for renal elimination or additive renal impairment could raise entecavir exposure.
What to do
No routine adjustment is needed. In patients with renal impairment on prolonged neomycin, monitor renal function and adjust entecavir dosing to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Neomycin?
MediHelp rates the interaction as minor. Entecavir and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entecavir is eliminated mainly by the kidney, and drugs that impair renal function can raise its concentrations. Oral neomycin has minimal systemic absorption, so a meaningful effect is unlikely unless significant absorption and nephrotoxicity occur.
How serious is the interaction between Entecavir and Neomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. In patients with renal impairment on prolonged neomycin, monitor renal function and adjust entecavir dosing to creatinine clearance.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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