Drug interactions
Entecavir + Pemetrexed
Severity: Minor
Entecavir and Pemetrexed: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are eliminated renally, and pemetrexed can cause renal toxicity and depends on tubular secretion. Impaired kidney function could raise entecavir exposure, and competition for secretion is theoretically possible.
What this interaction means in plain words
Entecavir and Pemetrexed have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entecavir belongs to Anti Virals; Pemetrexed belongs to Oncology.
Why it happens
Potential competition for renal tubular secretion and pemetrexed-associated renal impairment reducing entecavir clearance.
What to do
Monitor renal function during pemetrexed therapy and adjust the entecavir dose to creatinine clearance if it falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entecavir
Other interactions of Pemetrexed
Frequently asked questions
Can I take Entecavir with Pemetrexed?
MediHelp rates the interaction as minor. Entecavir and Pemetrexed have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are eliminated renally, and pemetrexed can cause renal toxicity and depends on tubular secretion. Impaired kidney function could raise entecavir exposure, and competition for secretion is theoretically possible.
How serious is the interaction between Entecavir and Pemetrexed?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function during pemetrexed therapy and adjust the entecavir dose to creatinine clearance if it falls.
What other medicines interact with Entecavir?
MediHelp also lists interactions of Entecavir with, for example, Alogliptin-metformin, Canagliflozin-metformin, Cidofovir. The full list is on the Entecavir page.
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