Drug interactions
Entecavir + Sulindac
Severity: Minor
Entecavir and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir is eliminated by glomerular filtration and tubular secretion, and NSAIDs may reduce renal function or compete for secretion. Entecavir concentrations could rise, though clinically important effects have not been well documented.
What this interaction means in plain words
Entecavir and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entecavir belongs to Anti Virals; Sulindac belongs to Musculoskeletal.
Why it happens
Possible reduction in renal clearance through NSAID effects on renal perfusion and competition for tubular secretion.
What to do
Monitor renal function periodically during concurrent use and adjust entecavir dosing if creatinine clearance declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Sulindac?
MediHelp rates the interaction as minor. Entecavir and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entecavir is eliminated by glomerular filtration and tubular secretion, and NSAIDs may reduce renal function or compete for secretion. Entecavir concentrations could rise, though clinically important effects have not been well documented.
How serious is the interaction between Entecavir and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function periodically during concurrent use and adjust entecavir dosing if creatinine clearance declines.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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