Drug interactions
Entrectinib + Leuprolide
Severity: Moderate
Entrectinib and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and leuprolide-related androgen deprivation may do the same. The combination may increase the risk of torsades de pointes.
What this interaction means in plain words
Entrectinib and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Perform baseline and periodic ECG and electrolyte monitoring. Follow entrectinib labeling for dose reduction or interruption if QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Leuprolide?
MediHelp rates the interaction as moderate. Entrectinib and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval, and leuprolide-related androgen deprivation may do the same. The combination may increase the risk of torsades de pointes.
How serious is the interaction between Entrectinib and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform baseline and periodic ECG and electrolyte monitoring. Follow entrectinib labeling for dose reduction or interruption if QTc is prolonged.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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