Drug interactions
Entrectinib + Posaconazole
Severity: Major
Entrectinib and Posaconazole: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole raises entrectinib exposure and both agents can prolong the QT interval. This increases the risk of entrectinib toxicity such as CNS effects and heart failure, and of arrhythmia.
What this interaction means in plain words
Entrectinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition increases entrectinib levels, with additive QT prolongation.
What to do
Avoid the combination. If unavoidable, reduce the entrectinib dose per labeling, monitor ECG and electrolytes, and resume the prior dose after the inhibitor washout.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Posaconazole?
MediHelp rates the interaction as major. Entrectinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole raises entrectinib exposure and both agents can prolong the QT interval. This increases the risk of entrectinib toxicity such as CNS effects and heart failure, and of arrhythmia.
How serious is the interaction between Entrectinib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If unavoidable, reduce the entrectinib dose per labeling, monitor ECG and electrolytes, and resume the prior dose after the inhibitor washout.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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