Drug interactions
Entrectinib + Prochlorperazine
Severity: Moderate
Entrectinib and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and prochlorperazine can add to this effect. The combination may increase the risk of torsades de pointes, especially with electrolyte disturbances or heart disease.
What this interaction means in plain words
Entrectinib and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium. Monitor the QTc during combined therapy and adjust or withhold entrectinib if prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Prochlorperazine?
MediHelp rates the interaction as moderate. Entrectinib and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval, and prochlorperazine can add to this effect. The combination may increase the risk of torsades de pointes, especially with electrolyte disturbances or heart disease.
How serious is the interaction between Entrectinib and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium. Monitor the QTc during combined therapy and adjust or withhold entrectinib if prolonged.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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