Drug interactions
Enzalutamide + Erythromycin
Severity: Moderate
Enzalutamide and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can lower erythromycin concentrations, potentially reducing antibacterial efficacy. Enzalutamide exposure is probably not significantly altered by erythromycin, a moderate CYP3A4 inhibitor.
What this interaction means in plain words
Enzalutamide and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Erythromycin belongs to Anti Bacterial.
Why it happens
Enzalutamide induces CYP3A4 and increases the metabolism of erythromycin.
What to do
Monitor clinical response to the antibiotic and consider an alternative antibiotic that is not a CYP3A4 substrate, such as a different class, if treating a serious infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Erythromycin?
MediHelp rates the interaction as moderate. Enzalutamide and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can lower erythromycin concentrations, potentially reducing antibacterial efficacy. Enzalutamide exposure is probably not significantly altered by erythromycin, a moderate CYP3A4 inhibitor.
How serious is the interaction between Enzalutamide and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to the antibiotic and consider an alternative antibiotic that is not a CYP3A4 substrate, such as a different class, if treating a serious infection.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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